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Dr. Zahra Noroozi

EDUCATION 

Ph.D. in Mechanical Engineering, June 2011
Mechanical Engineering Department, University of California, Irvine,                  Dissertation: “Centrifugal Microfluidic Systems for Fast and Automated Biological Assays”

Bachelor degree in Information & Computer Science, December 2002
School of Information and Computer Science, University of California, Irvine

Masters of Science in Mechanical Engineering, September 1999
University of Mashad, Mashad, Iran
M.S. Thesis:  Approximation Methods in Droplet Growth Equation Solutions in a
Convergent – Divergent Nozzle. Two approximation methods were suggested and a reduction
in the calculation time of droplet growth was accomplished.

Bachelor of Science in Mechanical Engineering, September 1997
University of Shiraz, Shiraz, Iran
B.S. Project:  Thermal design of a Heat Exchanger – Complete thermal analysis of a shell and tube heat exchanger was programmed and the result was used in thermal design of “Mehr Niroo” Solar Power Plant in Shiraz, Iran.


RESEARCH EXPERIENCE

University of California, Irvine, CA

Graduate Student

Design and fabrication of a fully automated CD-based microfluidic systems for solid-state detection of proteins.

  • Fabricated multilayer CD fluidic systems
  • Designed an electric circuit for timely delivery of current to the rotating platform 
using a slip-ring/brush assembly.
  • Performed analytical modeling of upstream delivery of liquids on a rotating
  • Studied multiple methods for controlled delivery of liquids on a rotary platform. 
Design and fabrication of a semi-automated multiplexed CD-based system for faster

protein microarray processing.

  • Utilized the reciprocation technique to enhance interactions between molecules in the liquid and solid phase.
  • Performed numerical modeling of antigen-antibody interactions to optimize the assay parameters.
  • Fabricated disposable microfluidic units by layered assembly of plastic parts and pressure sensitive adhesives. 
Modeling of the temperature management during deferent stages of a DNA diagnostic assay on a CD microfluidic platform.
  • Studied the heating and cooling rates as a function of channel wall thickness, rotational velocity, channel geometries, and the volume of liquids.

Design and fabrication of a centrifugal microfluidic system for reciprocating liquids.

  • Performed photolithography and soft lithography techniques to fabricate microfluidic units made of PDMS slabs and glass slides.
  • Demonstrated the use of flow reciprocation principle for mixing two nanoliter to microliter volumes of fluids.
  • Demonstrated the use of flow reciprocation principle for performing fast DNA microarray processing. 
Modeling of the actuating flaps in a microliter size chamber.
  • Studied active mixing in a laminar flow dominated regime.

Modeling of solid-state DNA hybridization reaction in microchannels with different geometries and sizes.

  • Studied the effect of channel geometries on the rate of reaction between 
molecules in liquid and solid phase.
  • Studied the effect of sample flow rate on the rate of reaction.
  • Studied the effect of sample concentration and density of immobilized DNA 
molecules on the rate of reaction.

     

PUBLICATIONS

Book chapters

Kulinsky L., Noroozi Z., and Madou M. Present Technology and Future Trends in Point of Care Microfluidic Diagnostics. Microfluidic Diagnostics: Methods and Protocols, Volume 1: Fabrication and Manipulation Protocols. Edited by Mansfield, C. D. and Jenkins G. Humana Press. 2011.

Journal Publications

Noroozi Z, Kido H, and Madou MJ. Electrolysis-Induced Pneumatic Pressure for Control of Liquids in a Centrifugal System. Journal of The Electrochemical Society. 2011. 158 (11) P130- P135.

Noroozi Z, Kido H, Peytavi R, Nakajima-Sasaki R, Jasinskas A, Micic M, Felgner PL, Madou MJ. A multiplexed immunoassay system based upon reciprocating centrifugal microfluidics. Rev. Sci. Instrum. 82, 064303 (2011).

Noroozi Z, Kido H, Micic M, Pan H, Bartolome C, Princevac M, et al. Reciprocating flow-based centrifugal microfluidics mixer. Review of Scientific Instruments 2009;80:075102.

Conference Papers

Noroozi Z, Kido H, PeytaviR, Sasaki R, Jasinskas A, Felgner PL, Madou MJ, Centrifugal Fluidic System for Enhanced Mixing and Reducing Incubation Times During Protein Microarray Processing, Proceedings of μTAS Conference, Groningen, The Netherlands (2010).

Sarma A, Zahra Noroozi, and Andre van derHoek, “Palantir: Raising Awareness among Configuration Management Workspaces”, Proceedings of theTwenty-Fifth International Conference on Software Engineering, Portland, Oregan (2003).

AWARDED PATENTS
Patent number: 9456924

Abstract: A valve system for an ocular implant device that includes a deformable membrane comprising a piezo-based material, an actuating element to apply pressure to the membrane to deform the membrane into a position that obstructs fluid flow from the inlet, and a control system to detect a position of the membrane based on measured electrical properties of the membrane.


 OTHER PROFESSIONAL EXPERIENCES

Alcon Laboratories

Research & Development Scientist, 2011-2014

  • Managed and supervised the cleanroom facility at Alcon Lake Forest Facility.
  • Designed and assembled MEMS components for surgical instrumentation.
  • Designed microfluidic components for bubble-free and leak-free transportation of biological liquids at desired pressures and flow rates.
  • Designed goal-oriented test procedures and prepared test protocols and experiment reports.
  • Prepared memorandums of inventions (MOIs)

 Grace Bio-Labs Inc, Bend, OR

Project Scientist,2011

  • Designed and fabricated a multilayer circular disk (CD)-based system for performing fully automated membrane-based immunoassays.
  •   Conducted assays using human serum, reagents and buffers.

Coast to Coast Mortgage Services, Laguna Hills, CA , 2003-2005

Software Developer

  • Designed and developed a 3-tier object oriented system for tracking
  • ‘Preservation Orders’ using VB.NE, ADO.NET, and ASP.NET.
  • Maintained the company database for tracking orders.

    Pernova, Irvine, CA, 2003

    Software Developer

  • Coded new modules for a Hotel Booking software developed in C++.
  •   Utilized DOM/SAX parsers and XML for transfer of reservation information.
  •   Converted existing Access databases to SQL Server 2000.

    PIEDEC Industries, Shiraz, Iran, 1997

    Design Engineer

  • Conducted feasibility study, layout design, and stress analysis of piping systems in Oil, Gas, and Petrochemical industry projects.

OTHER ACADEMIC APPOINTMENTS

University of California, Irvine
Adjunct Professor, Department of Mechanical and Aerospace Engineering,2009-present

  • Introduction to Thermodynamics 2009-Present
  •   Computer Aided Design
  •  Introduction to Fluid Mechanics

University of California Irvine

Teaching Assistant, Department of Mechanical and Aerospace Engineering

  •  Introduction to Thermodynamics,2008
  • Fluid/Thermal Laboratory,2009

Skills

FABRICATION SKILLS

Photolithography, Soft Lithography, Deep Reactive Ion Etching (DRIE), Wet Etching Scanning Electron Microscopy (SEM), Laser cutting, CNC Machining, Basic Electronics.

COMPUTER SKILLS

Programming: Java, C++, HTML, JavaScript, Servlet/Jsp, XML, VB.NET, ASP.NET, Matlab Applications: CAD (AutoCAD, SolidWorks, Pro/Engineer), Comsol, Matlab, Autodesk Inventor, Autodesk Simulation